Vaccines for Enteric Diseases

16-18 October 2019, CHUV, University of Lausanne, Lausanne, Switzerland

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Posters

Final Conference Programme

Poster 101
‘Molecular lipopolysaccharide enteric vaccines: From development to clinical application’

Vladimir A. Ledov1, Marina E. Golovina1, Anna A. Markina1, Yuri A. Knirel3, Vyacheslav L. L’vov1, Alexander L. Kovalchuk2 and Petr G. Aparin1
(1 National Research Center-Institute of Immunology, Federal Medical Biological Agency of Russia, Moscow, Russia; 2 The Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, Maryland, USA; 3 N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia)

Poster 102
‘ClinEpiDB: The clinical epidemiology database resource’
Cristina Aurrecoechea2, Brian P. Brunk1, Danielle Callan1, Dave Falke2, Steve Fischer1, Danica Helb1, Jay Humphrey2, John Judkins1, Jessica C. Kissinger2, Brianna Lindsay1, David S. Roos1, Sheena Shah Tomko1, Christian J. Stoeckert, Jr1 and Jie Zheng1
(1 University of Pennsylvania, Philadelphia, Pennsylvania, USA; 2 University of Georgia, Athens, Georgia, USA)

Poster 103
‘Superior breadth of secretory IgA response by apyrase expressing vaccines’
Lisa Perruzza
(Institute for Research in Biomedicine, Bellinzona, Switzerland)

Poster 104
‘Characterization of the Antibody in Lymphocyte Supernatant (ALS) assay after oral immunization with Shigella sonnei WRSs2 and WRSs3 and correlation with systemic and mucosal immune responses’
Malabi Venkatesan1, Jill El-Khorazaty2, Monica McNeal 3, Cassandra Ballou2 Shoshana Barnoy1, Michelle Dickey3, Robert W Frenck Jr3 and Shahida Baqar4
(1 Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA; 2 The Emmes Company, LLC, Rockville, Maryland, USA; 3 Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA and Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA; 4 Enteric and Sexually Transmitted Infections Branch, Division of Microbiology & Infectious Diseases, NIAID, NIH, Bethesda, Maryland, USA)

Poster 105
‘Preclinical evaluation of a live attenuated Salmonella enterica serovar Newport vaccine’
Shamima Nasrin, Fabien J. Fuche, Khandra T. Sears, Jennifer Jones, Myron M. Levine, Raphael Simon and Sharon M. Tennant
(Center for Vaccine Development and Global Health, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA)

Poster 106
‘The occurrence of cholera in Africa is associated with drought conditions’
Sean M. Moore1,2, Alan Costello1, Elizabeth C. Lee3, Andrew S. Azman3, Justin Lessler3 and Ben Zaitchik4
(1 Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA; 2 Institute of Global Health, University of Notre Dame, Notre Dame, Indiana, USA; 3 Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA; 4 Department of Earth and Planetary Sciences, Johns Hopkins University, Baltimore, Maryland, USA)

Poster 107
‘A multiplex ELISA for evaluating environmental enteric dysfunction interventions and vaccine immunogenicity’
Michael B. Arndt1,2, Jason L. Cantera1, Laina D. Mercer1, Michael Kalnoky1, Heather N. White1, Gregory Bizilj1, David S. Boyle1, Eugenio L. de Hostos1 and Robert K.M. Choy1
(1 PATH, Seattle, Washington, USA; 2 Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, USA)

Poster 108
‘A novel approach to develop a Shigella vaccine using adenoviral vector platform’
Young-Hye Moon1,2, Min Jung Kim1, Seonghun Jeong1, Young-Shin Park1, Manki Song1 and Jae-Ouk Kim1
(1 Clinical Research Lab, International Vaccine Institute, Seoul National University Research Park, Seoul, South Korea; 2 Laboratory of Immune Regulation, College of Pharmacy, Seoul National University, Seoul, South Korea)

Poster 109
‘Enteric surveillance reveals viral etiology of acute gastroenteritis in US military training facilities’
Melissa S. Anderson1, Scott Vo1, Melinda S. Balansay1, Michael A. Zundel2, Paul C.F. Graf2, Ewell M. Hollis2 and Christopher A. Myers2
(1 General Dynamics Information Technology, San Diego, California, USA; 2 Naval Health Research Center, San Diego, California, USA)

Poster 110
‘Adjuvant activity of dmLT in immune cells from infants and adults’
Marjahan Akhtar1, Nuder Nower Nizam1, Salima Raiyan Basher1, Lazina Hossain1, Sarmin Akter1, Taufiqur Rahman Bhuiyan1, Firdausi Qadri1 and Anna Lundgren2
(1 International Centre for Diarrhoeal Disease Research, Bangladesh; 2 Department of Microbiology and Immunology, University of Gothenburg, Sweden)

Poster 111
‘Human neonatal Fc receptor is the cellular uncoating receptor for enterovirus B’
Xin Zhao1,4,15, Guigen Zhang2,15, Sheng Liu1,5,15, Xiangpeng Chen3,15, Ruchao Peng1, Lianpan Dai6, Xiao Qu1, Shihua Li1, Hao Song6, Zhengrong Gao7, Pengfei Yuan8, Zhiheng Liu2,9, Changyao Li1, Zifang Shang6, Yan Li1, Meifan Zhang1, Jianxun Qi1, Han Wang6, Ning Du6, Yan Wu6, Yuhai Bi1,4, Shan Gao10, Yi Shi1,4, Jinghua Yan1,4,11, Yong Zhang12,13, Zhengde Xie3, Wensheng Wei2 and George F. Gao1,4,6,12,14,16
(1 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; 2 Biomedical Pioneering Innovation Center (BIOPIC), Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China; 3 Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Virology Laboratory, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; 4 CAS Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China; 5 School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China; 6 Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China; 7 KunMing Institute of Zoology, Chinese Academy of Sciences, KunMing, China; 8 EdiGene Inc, Changping District, Beijing, China; 9 Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; 10 CAS Key Laboratory of Bio-medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China; 11 CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; 12 National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China; 13 WHO WPRO Regional Polio Reference Laboratory, NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; 14 Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China)

Poster 112
‘Validation of a human challenge model using an LT-expressing enterotoxigenic E. coli strain (LSN03-016011) and characterization of potential amelioration of disease by an investigational LT-ETEC vaccine candidate (VLA1701)’
Kawsar R. Talaat1, Chad K. Porter2, Subhra Chakraborty1, Brittany Feijoo1, Jessica Brubaker1, Brittany Adjoodani1, Michael Prouty2, Steven Poole2, David Sack1, Susanne Eder-Lingelbach3 and Christian Taucher3
(1 Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; 2 Naval Medical Research Center, Silver Spring, Maryland, USA; 3 Valneva, Austria GmbH, Austria)

Poster 113
‘Comparative immunogenicity of glycoconjugate vaccines delivering Shigella flexneri 6 O-antigen of differing lengths’
Maria Michelina Raso1,2, Gianmarco Gasperini1, Renzo Alfini1, Fabiola Schiavo1, Francesca Necchi1, Allan Saul1, Paola Cescutti2 and Francesca Micoli1
(1 GSK Vaccines Institute for Global Health (GVGH) S.r.l., Siena, Italy; 2 Dipartimento di Scienze della Vita, Università degli Studi di Trieste, Trieste, Italy)

Poster 114
‘Development, characterization, and immunological evaluation of parenterally delivered CS6-subunit vaccine candidates against enterotoxigenic E. coli (ETEC)’
Steven Poole1,2, Milton Maciel Jr.1,2, Amritha Ramakrishnan3, Yang Liu1,2, Kathleen Dori1,2 and Michael G. Prouty2
(1 Henry M. Jackson Foundation, Bethesda, Maryland, USA; 2 Naval Medical Research Center, Silver Spring, Maryland, USA; 3 Naval Medical Research Unit 6, Lima, Peru)

Poster 115
‘Characterization of cholera antigen-specific cells in blood and mucosa’
Taufiqur R. Bhuiyan1, Eric Safai2, Lazina Hossain1, Hasan Al Banna1, M. Hasanul Kaisar1, Fahima Chowdhury1, Ashraful Islam Khan1, Nur Haq Alam1, Richelle C. Charles3,4, Pavol Kovác5, Stephen B. Calderwood3,4, Phillip L. Felgner6, Jason B. Harris3,7,8, Doug S. Kwon2, Firdausi Qadri1 and Edward T. Ryan3,4,7
(1 Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh; 2 Ragon Institute, Harvard Medical School, Boston, Massachusetts, USA; 3 Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA; 4 Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA; 5 National Institute of Diabetes and Digestive and Kidney Diseases, Laboratory of Bioorganic Chemistry, National Institutes of Health, Bethesda, Maryland, USA; 6 Department of Medicine, University of California, Irvine, California, USA; 7 Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; 8 Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA)

Poster 116
‘Optimizing a disease severity scale for evaluation of vaccine and other preventive or treatment interventions for Travelers’ Diarrhea (TD) in adults’
N. Maier1, M.S. Riddle3, D. Tribble4, A.L. Bourgeois1 and C.K. Porter2
(1 PATH, 2 Naval Medical Research Center, Silver Spring, Maryland, USA; 3 Uniformed Services School of Health Sciences (USU), Bethesda, Maryland, USA; 4 Infectious Diseases Clinical Research Program, USU, Bethesda, Maryland, USA)

Poster 117
‘ClinEpiDB: the Clinical Epidemiology Database Resource’
Cristina Aurrecoechea2, Brian P. Brunk1, Danielle Callan1, Dave Falke2, Steve Fischer1, Danica Helb1, Jay Humphrey2, John Judkins1, Jessica C. Kissinger2, Brianna Lindsay1, David S. Roos1, Sheena Shah Tomko1, Christian J. Stoeckert, Jr1 and Jie Zheng1
(1 University of Pennsylvania, Philadelphia, Pennsylvania, USA; 2 University of Georgia, Athens, Georgia, USA)

Poster 118
‘An mRNA-based vaccine technology for next generation prophylactic vaccines against rotavirus’
Sandro Roier, Susanne Rauch and Benjamin Petsch
(CureVac AG, Tübingen, Germany)

Poster 119
‘Distribution of Campylobacter jejuni capsular genotypes: A new insight in low income countries’
Zhahirul Islam1, Israt Jahan1, Frédéric Poly2 and Hubert P. Endtz1,3,4
(1 Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr,b, Dhaka, Bangladesh; 2 Naval Medical Research Center, Silver Spring, Maryland, USA; 3 Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands; 4 Fondation Mérieux, Lyon, France)

Poster 120
‘Measurement of fecal inflammatory markers and their association with clinical outcomes in two Controlled Human Infection Models of Campylobacter jejuni
Heather Eggleston1,2, Christina L. Gariepy1,2, Frédéric Poly2, Chad K. Porter2, David R. Tribble3 and Renee M. Laird1,2
(1 Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA; 2 Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA; 3 Infectious Disease Clinical Research Program, Preventive Medicine and Biostatistics Department, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA)

Poster 121
‘Protection from Clostridium difficile infection by apyrase-bearing oral vaccine’
M. Raneri, L. Perruzza, M. Scantamburlo and F. Grassi
(Institute for Research in Biomedicine, Bellinzona, Switzerland)

Poster 122
‘Comparative immunogenicity of glycoconjugate vaccines delivering Shigella flexneri 6 O-antigen of differing lengths’
Maria Michelina Raso1,2, Gianmarco Gasperini1, Renzo Alfini1, Fabiola Schiavo1, Francesca Necchi1, Allan Saul1, Paola Cescutti2 and Francesca Micoli1
(1 GSK Vaccines Institute for Global Health (GVGH) Siena, Italy; 2 Dipartimento di Scienze della Vita, Università degli Studi di Trieste,Trieste, Italy)

Poster 123
‘Establishment of a human colonoid model to study Shigella pathogenesis and evaluate vaccine candidates’
Sri Ranganathan, Chris Grassel and Eileen M. Barry
(Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA)

Poster 124
‘Vaccination with a Campylobacter jejuni conjugate vaccine CJCV2 administered with liposomes containing monophosphoryl lipid A and QS-21 is protective in a zinc-deficient C. jejuni mouse model’
Christina L. Gariepy1,2, Heather Eggleston1,2, Nina M. Shoemaker1,2, Mario A. Monteiro3, Zoltan Beck1,4, Gary R. Matyas4, Frédéric Poly2 and Renee M. Laird1,2
(1 Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA; 2 Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA; 3 Department of Chemistry, University of Guelph, Guelph, Ontario, Canada; 4 U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA)

 

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