Plant-Based Vaccines, Antibodies & Biologics

5-7 June 2013, University of Verona, Italy

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Day Two

Final Conference Programme | Thursday 6th June

SESSION 5:
ANTIBODIES I

Moderator: Jim W. Larrick (Panorama Research, Mountain View, California, USA)

09.00-09.30
‘Pharma-Planta – The European project to introduce plant-derived monoclonal antibodies to the clinic’
Rainer Fischer (RWTH Aachen, Aachen, Germany)

09.30-09.50
‘Development of a Nicotiana-derived version of Synagis (anti-RSV)’
Larry Zeitlin, Ognian Bohorov, Natasha Bohorova, Charles Goodman, Andrew Hiatt, Do Kim, Michael Pauly, Jesus Velasco, Kevin J. Whaley, Dale L. Barnarda, James E. Crowe, Jrb, Pedro A. Piedra, Brian E. Gilbert (MAPP Biopharmaceuticals, San Diego, California, USA)

09.50-10.05
‘Development of a passive immunization cocktail for HIV using plant-based antibodies’
Wing-Fai Cheung, Erin Gilbert, John Treat, Jessica Rouleau, Linda Veldhuis, Fang Lui, Zacherie LeBlanc, Haifeng Wang, Michael Marit, Michael D. McLean, David Willer, Kelly MacDonald and J. Christopher Hall (PlantForm Corporation/University of Guelph, Guelph, Ontario, Canada)

10.05-10.20
‘Functional analysis of plant-derived MAb therapeutics for West Nile Virus with multiple specificities’
Qiang ‘Shawn’ Chen, Huafang Lai, Matthew Dent, Junyun He, Xiachong Zhou, Kahlin Leuzinger, Jake Stahnke, Jonathan Hurtado, Reshma Kumar and Christopher Brock (Arizona State University, Tempe, Arizona, USA)

10.20-10.35
‘Biogeneric antibodies made in plants’
Victor Klimyuk (Icon Genetics GmbH, Halle (Saale), Germany)

10.35-10.50
‘Lama antibodies inspired simple porcine IgAs produced in Arabidopsis seeds reduced entertoxigenic Escherchia coli infection on oral administration in piglets’
Vikram Virdi, Annelies Coddens, Sylvie De Buck, Sam Miller, Bruno Goddeeris, Eric Cox, Henri De Greve and Ann Depicker (VIB, University of Gent, Gent, Belgium)

10.50-11.05
‘Production of bivalent VHH-Fc antibodies in Arabidopsis thaliana seeds, Nicotiana benthamiana leaves and Pichia pastoris
Thomas De Meyer, Jonah Nolf, Sylvia De Buck and Ann Depicker (VIB-PSB/University of Gent, Gent, Belgium)

11.05-11.30
Coffee Break & Posters

SESSION 6:
VACCINES II

Moderator: Julian Ma (St. George’s University of London, London, UK)

11.30-12.00
‘Developing plant-made influenza vaccines: From discovery to commercial scale production’
Marc-Andre D’Aoust (Medicago Inc., Quebec, Canada)

12.00-12.30
‘Preclinical evaluation of VLP-based malaria transmission blocking vaccine’
Konstantin Musiychuk and Vidadi Yusibov (Fraunhofer USA Center for Molecular Biotechnology, Newark, Delaware, USA)

12.30-12.55
‘PRX-102, modified alfa-galactosidase enzyme for treating Fabry disease- Product development’
Yoseph Shaaltiel (Protalix Biotherapeutics, Carmiel, Israel)

12.55-13.15
‘Testing an HIV vaccine using live Vaccinia virus and plant-produced Gag and dgp41 virus-like particles’
Lydia R. Meador, Sarah A. Kkessans, Jacquelyn Kilbourne, Karen L. Denzler, Karen Kibler, Bertram L. Jacobs and Tsafrir S. Mor (Arizona State University, Tempe, Arizona, USA)

13.15-13.35
‘Safety and efficacy of plant-produced Griffithsin for antiviral indications’
Daniel Tusé (Intrucept Biomedicine, Owensboro, Kentucky, USA) and Kenneth E. Palmer (Intrucept Biomedicine/University of Louisville School of Medicine, Owensboro, Kentucky, USA)

13.35-14.30
Lunch Break & Posters

SESSION 7:
MANUFACTURING & PRODUCTION SYSTEMS DEVELOPMENTS

Moderator: Edward P. Rybicki (University of Cape Town, Cape Town, South Africa)

14.30-14.50
‘Plant virus-based systems in autoimmune diseases: From screening to treatment’
Linda Avesani, M. Merlin, R. Zampieri, E. Tinazzi, E. Gecchele and M. Pezzotti (University of Verona, Verona, Italy)

14.50-15.10
‘BryoTechnology™ en route to the clinic’
Andreas Schaaf (Greenovation Biotech GmbH, Freiburg, Germany)

15.10-15.25
‘CoMoFarm – Contained molecular farming: Controlled contained systems for high yield and consistency’
Stefan Schillberg (Fraunhofer IME, Aachen, Germany)

15.25-15.40
‘Hydroponic cultivation of tobacco for the production of recombinant pharmaceutical proteins by rhizosecretion’
Pascal Drake (St. George’s University of London, London, UK)

15.40-15.55
‘Genetic engineering of Nicotiana benthamiana to improve recombinant protein production’
Ling Yuan, Sanjay Singh, Muqiang Gao, David Zaitlin, Rich Mundell and Orlando Chambers
(KTRDC, University of Kentucky, Lexington, Kentucky, USA)

15.55-16.10
‘Development of suspension cells as a competitive production system for antibodies’
Bertrand Magy, Jeremie Tollet, Marc Boutry and Catherine Navarre (University Catholique de Louvain, Louvain, Belgium)

16.10-16.25
‘Molecular farming: Regulatory developments’
Juergen Drossard (RWTH Aachen, Aachen, Germany)

16.25-16.45
Tea Break & Posters

SESSION 8:
INTERACTIVE DISCUSSION SESSION:

16.45-18.00
‘Commercialisation of molecular pharming products – objectives and targets for the next 5 years’

Lead Moderators:
Hugh Haydon (Kentucky Bioprocessing LLC, Owensboro, Kentucky, USA)
Julian Ma (St. George’s University of London, London, UK)

Including:
‘Solmab, Inc., an integrated PMP Development and commercialization enterprise’
Hugh Haydon (Kentucky Bioprocessing LLC, Owensboro, Kentucky, USA)

Expert Panel:
Einat Almon, John Butler, Kevin Whaley, Scott Deeter and Marc-Andre D’Aoust

Evening
PBVA 2013 Conference Dinner

 

PBVA 2013 Venue & Hotel Map

PBVA 2013 Venue & Hotel Map

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PBVA 2013 Sponsors

  • John Innes Centre
  • Angany Genetics
  • Greenovation
  • ILVO
  • Icon Genetics
  • EPSO
  • Molecular Farming
  • Kentucky Bioprocessing
  • Fraunhofer USA
  • Retroscreen Virology
  • Ventria Bioscience
  • BioVaxx
  • Mapp Biopharmaceutical
  • Fraunhofer IME
  • Aldevron
  • Nomad Biosciences
  • DNA Vaccine
  • Intrucept Biomedicine
  • DSM
  • Plant Transformation Technologies
  • Synthon
  • iBioPharma
  • NexGen
  • Root Lines Technology
  • Medicago
  • Protalix Biotherapeutics

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